RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-451a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
bioinformatics analysis;a luciferase reporter assay
Target
TBX1
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-451a attenuates angiotensin II-induced cardiac fibrosis and inflammation by directly targeting T-box1
Year
2022
Function
"MiR-451a directly targeted TBX1 expression, which inhibited TGF-beta1 production in both cardiac myocytes and fibroblasts, inactivating of TGF-beta1/SMAD2/3 signaling, inhibiting myofibroblast differentiation and proinflammatory cytokine expression, and leading to attenuation of cardiac fibrosis and inflammation."